In partnership with the European Space Agency (ESA) and the faculty of Aerospace and Architecture at the Massachusetts Institute of Technology (MIT), this paper presents space architecture and master planning strategies for the first full-time human settlement on the Moon. One aspect of ESA’s space exploration efforts in Low Earth Orbit, the Moon, and Mars is to aim at “developing new concepts for international exploration activities, encompassing novel cooperation opportunities open to all nations and industrial actors”. The partnership envisions future missions to the lunar surface that will be driven by cooperation and sustainable planning strategies. The “Moon Village” idea presented by the ESA Director General is a vision for an open architecture based on global cooperation among multiple nations and multiple partners combining their various expertise for the common objective of enabling long-term exploration of the lunar surface. Fundamental to achieving this goal will be the establishment of infrastructure on the Moon, relying on a myriad of architectures and surface system capabilities. As part of this larger effort, a strategic alignment with NASA’s 2018 Strategic Plan to “extend human presence deeper into space and to the Moon for sustainable long-term exploration and utilization” provides an essential paradigm for holistic thinking about humanity’s future in space.